Zorbium, made by Elanco, uses buprenorphine as its mu agonist. Buprenorphine is classified as a mu opioid partial agonist and is contained in Zorbium at a concentration of 20 mg/ml (administered as 21.56 mg of buprenorphine hydrochloride).
Following is a simplified version of how transdermal buprenorphine in Zorbium acts:
Understanding how buprenorphine works and how it's processed by a cat's body can be crucial. The fact that cats might handle the drug differently due to their unique biology could be a significant point. Specifically, the inability of cats to attach the drug to other substances for easier removal might mean that the drug or its by-products could have unexpected effects. Also, the variability in how quickly it acts and how long it lasts could mean that there isn't a one-size-fits-all dosing or effect.
Zorbium is a product specifically designed for use in cats, leveraging buprenorphine in a transdermal delivery system for pain management. While its intent is to provide a convenient and effective means of analgesia tailored to feline physiology, there have been concerning reports of adverse effects, including fatalities, linked to its use. Here’s an overview considering these reports:
Disclosed* Active Ingredients:
Disclosed* Inactive Ingredients:
*Certain proprietary or trade secret components may not be explicitly listed to protect Elanco's intellectual property and maintain competitive advantage. These undisclosed ingredients may be integral to the product’s unique formulation, enhancing its stability, efficacy, or application without compromising safety, as regulatory authorities require the disclosure of any component that could impact the product's safety or administration.
Buprenorphine is widely used in veterinary medicine due to its effectiveness in managing moderate to severe pain in animals, especially in cats and dogs. Besides Zorbium, there are several other formulations and products containing buprenorphine for veterinary use. Some of these include:
Each of these buprenorphine products is designed to address pain management in animals, with specific formulations making the medication suitable for different species, types of pain, and methods of administration. The choice of product typically depends on the animal's specific needs, the desired duration of pain relief, and the practical aspects of administering the medication.
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